Synthesis, Characterization, Structural Description, Micellization Behavior, DNA Binding Study and Antioxidant Activity of 4, 5 and 6‐Coordinated Copper(II) and Zinc(II) Complexes
Muhammad Iqbal, Amir Karim, Saqib Ali, Hazrat Bilal, Ata Ur Rehman
Abstract
Four mononuclear copper(II) and zinc(II) complexes were synthesized by the reaction of copper and zinc salts with 3,4‐dichlorophenylactic acid, 2‐bromophenylactic acid, biphenylacetic acid (O‐donor ligand) and bipyridine (N‐donor ligands) having the general formulae [(L) 2 Cu(bp)(H 2 O)] ( 1 ), [(BpA) 2 Cu(bp)] ( 2 ), [(L) 2 Zn(bp)(H 2 O)] ( 3 ) and [(L*) 2 Zn(bp)] ( 4 ) (L = 3,4‐dichlorophenylacetate, L* = 2‐bromophenylacetate bp = bipyridine, and BpA = biphenylacetate). Structures of all compounds were characterized through FT‐IR spectroscopy and X‐ray diffraction analysis. FT‐IR spectra of all complexes confirmed the binding mode of Cu‐O and Zn‐O. XRD data revealed that complexes 1 – 3 exhibited distorted octahedral arrangement, whereas complex 4 has a distorted tetrahedral environment. Micellization behavior was examined with anionic surfactant (SDS) by conductance measurement as well as absorption spectral analysis. DNA binding study was assessed through viscosity measurement and UV/Vis spectrophotometry. DPPH free radical scavenging assay was measured by UV/Vis spectrophotometry. The results showed nice biological potential of all the complexes.