Design, synthesis, and biological activity evaluation of novel tubulin polymerization inhibitors based on pyrimidine ring skeletons
Yingying Kang, Yuanyuan Pei, Jinling Qin, Yixin Zhang, Yongtao Duan, Hua Yang, Yongfang Yao, Moran Sun
Topics & Concepts
ChemistryPyrimidineMoietyTubulinStereochemistryCell cycleMicrotubuleMicrotubule polymerizationApoptosisStructure–activity relationshipPolymerizationBiochemistryIn vitroCell biologyBiologyOrganic chemistryPolymerSynthesis and biological activityClick Chemistry and ApplicationsSynthesis of Organic Compounds