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4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS/STING pathway

Yutong Wu, Wenting Xu, Zheng Li, Sheng Wang, Juan Wei, Meiyun Liu, Huanping Zhou, Quanfu Li, Xuan Shi, Xin Lv

2023International Immunopharmacology65 citationsDOI

Topics & Concepts

PyroptosisARDSIRF3Alveolar macrophagePharmacologyMitochondrial ROSOxidative stressReactive oxygen speciesIn vivoProinflammatory cytokineChemistryMedicineImmunologyCell biologyInflammationInflammasomeBiologyMacrophageIn vitroLungBiochemistryInnate immune systemInternal medicineImmune systemBiotechnologyInflammasome and immune disordersinterferon and immune responsesImmune cells in cancer
4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS/STING pathway | Litcius