Autocatalytic oncotherapy nanosystem with glucose depletion for the cascade amplification of hypoxia-activated chemotherapy and H<sub>2</sub>O<sub>2</sub>-dependent chemodynamic therapy
Yao Hu, Song Bai, Xingyu Fan, Fangfang Zhou, Botao Chen, Songwen Tan, Hui Xu, Anqiang Pan, Shuquan Liang, Yongju He
Abstract
into highly toxic ˙OH, guaranteeing highly efficient CDT. Together, TPZ@FeMSN-GOX could effectively kill cancer cells and significantly inhibit tumor growth, providing a good paradigm for effective tumor treatment.
Topics & Concepts
TirapazamineProdrugGlucose oxidaseChemistryTumor hypoxiaHypoxia (environmental)ChemotherapyReactive oxygen speciesCancer researchCombinatorial chemistryBiochemistryEnzymeOxygenRadiation therapyOrganic chemistryBiologyCytotoxicityMedicineInternal medicineIn vitroNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisCancer, Hypoxia, and Metabolism