Red cell–bound antibodies and transfusion requirements in hospitalized patients with COVID-19
Alessandra Berzuini, Cristiana Bianco, Cinzia Paccapelo, Francesco Bertolini, Giuliana Gregato, Alessandra Cattaneo, Elisa Erba, Alessandra Bandera, Andrea Gori, Giuseppe Lamorte, Maria Manunta, Laura Porretti, Nicoletta Revelli, Francesca Truglio, Giacomo Grasselli, Alberto Zanella, Stefania Villa, Luca Valenti, Daniele Prati
Abstract
Berzuini et al report the observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT). However, eluates did not react with any test cells but did react with red cells from other patients with COVID-19 that were DAT negative. This suggests that COVID-19 may modulate the red cell membrane and present novel antigenic epitopes.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)AntibodyRed blood cellRed CellMedicineVirologyCoombs testImmunology2019-20 coronavirus outbreakRed Blood Cell TransfusionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)EpitopeAntigenBlood transfusionInternal medicineOutbreakInfectious disease (medical specialty)DiseaseErythrocyte Function and PathophysiologyBlood groups and transfusionCOVID-19 Clinical Research Studies