Fabrication of an injectable BMSC-laden double network hydrogel based on silk fibroin/PEG for cartilage repair
Yajie Zhang, Yi Cao, Liwei Zhang, Hongbo Zhao, Tianyu Ni, Yuanshan Liu, Zhen An, Min Liu, Renjun Pei
Abstract
An injectable BMSC-encapsulated double network (DN) hydrogel was fabricated via silk fibroin (SF) and poly(ethylene glycol) (PEG), which could efficiently support the survival and proliferation of BMSCs in vitro as well as cartilage repair in vivo, and provides a new strategy for cartilage tissue engineering.
Topics & Concepts
FibroinBiocompatibilityMaterials scienceSILKFabricationPEG ratioCartilageComposite materialBiomedical engineeringNanotechnologyAnatomyAlternative medicineFinanceMedicinePathologyEconomicsMetallurgySilk-based biomaterials and applicationsKnee injuries and reconstruction techniquesOsteoarthritis Treatment and Mechanisms