Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors
Chenghao Pan, Wenwen Nie, Jiao Wang, Jiamin Du, Zhichao Pan, Jian Gao, Yang Lu, Jinxin Che, Hong Zhu, Haibin Dai, Binhui Chen, Qiaojun He, Xiaowu Dong
Topics & Concepts
ChemistryFibroblast growth factor receptor 4QuinazolineMetabolic stabilityHepatocellular carcinomaMicrosomeFibroblast growth factor receptorBiochemistryIn vitroReceptorPharmacologyCancer researchCombinatorial chemistryFibroblast growth factorBiologyFibroblast Growth Factor ResearchKruppel-like factors researchPI3K/AKT/mTOR signaling in cancer