Src family kinases inhibition by dasatinib blocks initial and subsequent platelet deposition on collagen under flow, but lacks efficacy with thrombin generation
Yiyuan Zhang, Scott L. Diamond
Topics & Concepts
DasatinibThrombinSykChemistryProto-oncogene tyrosine-protein kinase SrcPlateletFibrinClot retractionTyrosine kinaseSrc family kinasePlatelet activationPharmacologyKinaseMedicineInternal medicineImmunologySignal transductionBiochemistryChronic Myeloid Leukemia TreatmentsPlatelet Disorders and TreatmentsCoagulation, Bradykinin, Polyphosphates, and Angioedema