Transcribed Ultraconserved Regions in Cancer
Myron Gibert, Aditya Sarkar, Bilhan Chagari, Christian Roig-Laboy, Shekhar Saha, Sylwia Bednarek, Benjamin Kefas, Farina Hanif, Kadie Hudson, Collin Dube, Ying Zhang, Roger Abounader
Abstract
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
Topics & Concepts
BiologyGenomeComputational biologyCancerHuman genomeConserved sequenceGeneticsDNAGeneBase sequenceCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing