Copper-Catalyzed Sulfonylation/Cyclization of Pent-4-ynamides toward Sulfonyl-Functionalized Pyrrol-2-ones
Danhua Wu, Menglu Jiang, Juanjuan Wang, Wei Yu
Abstract
A domino sulfonylation/intramolecular C–N coupling/dehydrogenation reaction was realized between pent-4-ynamides and sulfonyl chlorides by catalysis of Cu(acac) 2 and 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthalene. The reaction provides a convenient approach to sulfonyl-functionalized pyrrol-2-ones. This method can also be applied to the synthesis of 3-alkylidene isoindolinones from 2-ethynyl-benzamides.
Topics & Concepts
SulfonylChemistryCatalysisCopperMedicinal chemistryCombinatorial chemistryOrganic chemistryAlkylSulfur-Based Synthesis TechniquesCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods