microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway
Lijuan Chen, Zhi Guo, Yongming Zhou, Jian Ni, Jianhua Zhu, Xu Fan, Xuexing Chen, Yiling Liu, Ziping Li, Hao Zhou
Abstract
experiments. Collectively, our findings reveal that the repression of AML cell-derived EVs containing miR-1246 inhibitor alters the survival of LSCs by inactivating the LRIG1-mediated STAT3 pathway.
Topics & Concepts
Myeloid leukemiamicroRNASTAT3LeukemiaCell biologyCancer researchViability assayApoptosisChemistryMicrovesiclesCell cultureBiologySignal transductionImmunologyBiochemistryGeneGeneticsExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases