Chiral Analysis of Pharmaceuticals Using NMR Spectroscopy: A Review
Vinod Kumar Vashistha
Abstract
Abstract Chirality recognition of pharmaceutical products plays a significant part in asymmetric synthesis, stereoselective catalysis, supramolecular chemistry, and the development of new drug substances. NMR spectroscopy is a potential technique utilized not only for the determination of chemical structure but also for chirality analysis. Three main approaches are developed for the assessment of the chirality of organic compounds through NMR spectroscopy that depends on the use of chiral discriminating agents such as chiral solvating agents, and chiral derivatizing agents. This article highlights the recent advances in chiral recognition of pharmaceutically important compounds using NMR spectroscopic methods.
Topics & Concepts
ChemistryChirality (physics)Supramolecular chemistryNuclear magnetic resonance spectroscopySpectroscopyCombinatorial chemistryEnantioselective synthesisStereoselectivityOrganic chemistryComputational chemistryCatalysisMoleculeChiral symmetryPhysicsQuantum mechanicsNambu–Jona-Lasinio modelQuarkMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyMetabolomics and Mass Spectrometry Studies