Presence of Mobile Tigecycline Resistance Gene <i>tet</i> (X4) in Clinical Klebsiella pneumoniae
Weishuai Zhai, Yingxin Tian, Mi Lu, Muchen Zhang, Huangwei Song, Yulin Fu, Tengfei Ma, Chengtao Sun, Li Bai, Yang Wang, Dejun Liu, Ying Zhang
Abstract
Tigecycline, the first member of glycylcycline class antibiotic, is often considered one of the effective antibiotics against multidrug-resistant (MDR) infections. However, the emergence and wide distribution of two novel plasmid-mediated tigecycline resistance genes, tet (X3) and tet (X4), pose a great threat to the clinical use of tigecycline.
Topics & Concepts
TigecyclineKlebsiella pneumoniaeMultiple drug resistanceMicrobiologyMobile genetic elementsAntibioticsBiologyPlasmidAntibiotic resistanceDrug resistanceGeneGeneticsEscherichia coliAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsMycobacterium research and diagnosis