Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows
Jelle De Vos, Dwight R. Stoll, Stephan Buckenmaier, Sebastiaan Eeltink, James P. Grinias
Abstract
The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
Topics & Concepts
WorkflowInstrumentation (computer programming)InjectorKey (lock)Computer scienceChromatographyProcess engineeringSystems engineeringEngineeringChemistryMechanical engineeringDatabaseComputer securityOperating systemAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis ApplicationsMass Spectrometry Techniques and Applications