Replication in Human Intestinal Enteroids of Infectious Norovirus from Vomit Samples
Marie Hagbom, Jenny Lin, Tina Falkeborn, Lena Serrander, Jan Albert, Johan Nordgren, Sumit Sharma
Abstract
A typical clinical symptom of human norovirus infection is projectile vomiting. Although norovirus RNA and viral particles have been detected in vomitus, infectivity has not yet been reported. We detected replication-competent norovirus in 25% of vomit samples with a 13-fold to 714-fold increase in genomic equivalents, confirming infectious norovirus.
Topics & Concepts
NorovirusVirologyMurine norovirusInfectivityBiologyMicrobiologyDiarrheaViral replicationAcute gastroenteritisHuman bocavirusVomitingVirusMedicineRespiratory systemRespiratory tract infectionsPathologyAnatomySurgeryViral gastroenteritis research and epidemiologyViral Infections and Immunology ResearchAnimal Virus Infections Studies