Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits
Matthew J. Broadhead, Gareth B. Miles
Abstract
imaging demonstrated increased activity in astrocytes during locomotor-related output and in response to the direct stimulation of spinal neurons. Finally, astrocytes were found to respond to neuronally-derived glutamate in a metabotropic glutamate receptor 5 (mGluR5) dependent manner, which in turn drives astrocytic modulation of the locomotor network. Our work identifies bi-directional signaling mechanisms between neurons and astrocytes underlying modulatory feedback control of motor circuits, which may act to constrain network output within optimal ranges for movement.
Topics & Concepts
NeuroscienceAstrocyteBiologyCentral nervous systemNeuroscience and Neuropharmacology ResearchSleep and Wakefulness ResearchNeuroscience of respiration and sleep