Cobalt(III)‐Catalyzed Synthesis of Fused Quinazolinones by C–H/N–H Annulation of 2‐Arylquinazolinones with Alkynes
Subramani Kumaran, Kanniyappan Parthasarathy
Abstract
A convenient and efficient Co III ‐catalyzed cyclization of 2‐arylquinazolinones with alkynes is described. The electron donating as well as withdrawing groups and also halide substituted quinazolinones are compatible with this reaction. This catalytic reaction is highly regioselective with unsymmetrical alkynes. A possible mechanism, involves a formation of five‐membered metallacycle I by metal‐catalyzed aromatic C–H bond activation, alkyne insertion, seven‐membered metallacycle intermediates followed by reductive elimination to give a final product.
Topics & Concepts
MetallacycleChemistryAnnulationAlkyneRegioselectivityCatalysisCobaltMedicinal chemistryHalideBicyclic moleculeCombinatorial chemistryStereochemistryOrganic chemistryX-ray crystallographyOpticsPhysicsDiffractionQuinazolinone synthesis and applicationsCatalytic C–H Functionalization Methods