Lipodystrophy as a Late Effect after Stem Cell Transplantation
Daniel Tews, Ansgar Schulz, Christian Denzer, Julia von Schnurbein, Giovanni Ceccarini, Klaus‐Michael Debatin, Martin Wabitsch
Abstract
Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy.
Topics & Concepts
MedicineLipodystrophyHematopoietic stem cell transplantationTransplantationDiseaseStem cellInternal medicineImmunologyHuman immunodeficiency virus (HIV)GeneticsViral loadBiologyAntiretroviral therapyNuclear Structure and FunctionDiabetes and associated disordersHematopoietic Stem Cell Transplantation