Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses
Manoela V. Fogaça, Min Wu, Chan Li, Xiaoyuan Li, Marina R. Picciotto, Ronald S. Duman
Topics & Concepts
NeuroscienceInterneuronGABAergicParvalbuminAntidepressantSynaptic plasticityMuscarinic acetylcholine receptorBiologyNeuroplasticityPsychologyInhibitory postsynaptic potentialReceptorHippocampusBiochemistryNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingTreatment of Major Depression