Biocompatibility of Ti-6Al-4V titanium alloy implants with laser microgrooved surfaces
Qingchun Zheng, Lulu Mao, Yutao Shi, Weihua Fu, Yahui Hu
Abstract
The successful implantation depends on the favorable biocompatibility of the implant. In this paper,microgrooves on the surface of Ti-6Al-4V titanium alloy implants were made by laser processing technology,scanning electron microscopy and surface profilometer were used to observe the laser textured titanium samples,firstly. Then, the liquid-solid contact angle-measuring instrument was used to characterize the wettability of titanium samples. Finally,using a microplate reader and laser confocal microscope, the cytological behavior of cell proliferation, adhesion, differentiation, and cell morphology on the surface of different samples were studied.It showed that laser microgrooved surfaces had reduced liquid-solid contact angles,increased surface roughness,and better proliferation and differentiation of osteoblasts, while most cells grew along the microgrooves. These results indicate that the increased wettability provides a better growth environment for cell growth. Microgrooves are crucial in cell contact guidance, while their parameters control cell behavior and deserve an in-depth study.