Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance
Nicholas Mikolajewicz, Kui Zhai, Anish N. Puri, Petar Miletic, Nazanin Tatari, Jiarun Wei, Neil Savage, Zhi Huang, Qian Huang, Seon Yong Lee, Mahta Jan-Ahmadnejad, Roseanne Nguyen, David Chen, Tiegan Korman, Daniel Mobilio, Max Topley, Jack Qinyu Lu, Matthew R. Voisin, Zsolt Zádor, Shawn C. Chafe, Chitra Venugopal, Kevin R. Brown, Gelareh Zadeh, Hong Han, Julien Muffat, Shideng Bao, Sheila K. Singh, Jason Moffat
Topics & Concepts
Cancer researchCCL3GliomaBiologyChemokineTumor microenvironmentCCL5Chemokine receptorDruggabilityGene knockdownCXCL2CytokineGlial tumorDownregulation and upregulationMaravirocStem cellImmunologyInterferonCytotoxic T cellMicrogliaU87CCL2CXCL9Neural stem cellParacrine signallingCXCL14CXCL10ReceptorT cellCCR2Central nervous systemCell growthCell cultureCell biologySecretionGlioma Diagnosis and TreatmentNeurogenesis and neuroplasticity mechanismsChemokine receptors and signaling