Microneedle patch with “spongy coating” to co-load multiple drugs to treat multidrug-resistant melanoma
Xinfang Li, Weijiang Yu, Jingshuang Yang, Yonghang Chen, Xuedan Qian, Jing Wang, Youxiang Wang, Jian Ji
Abstract
experiments proved that CBP/SAHA co-loaded PF-MNP had the best therapeutic efficiency for multidrug-resistant melanoma. The MNP with a "spongy coating" showed potential to be a safe and efficient transdermal delivery platform for multiple drugs.
Topics & Concepts
Multiple drug resistanceMelanomaCoatingChemistryMedicineCancer researchNanotechnologyDrug resistanceMaterials scienceMicrobiologyBiologyAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesAdvanced Drug Delivery Systems