Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
Xiqiong Han, Wenqi Ma, Yi Zhu, Xuejiao Sun, Naifeng Liu
Topics & Concepts
Macrophage polarizationPDK4GlycationPyruvate dehydrogenase complexInflammationCell biologyDownregulation and upregulationPyruvate dehydrogenase kinaseInternal medicineMacrophageCancer researchDiabetes mellitusEndocrinologyMedicineChemistryImmunologyBiologyBiochemistryIn vitroEnzymeGeneAdvanced Glycation End Products researchImmune cells in cancerAdipokines, Inflammation, and Metabolic Diseases