Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function
Kimberly Veliz, Feng Shen, Olga Shestova, Maksim Shestov, Alexander A. Shestov, Sara Sleiman, Tyler Hansen, Roddy S. O’Connor, Saar Gill
Abstract
. CD38 is a multifunctional ectoenzyme with hydrolase and cyclase activities. Reintroduction of CD38 mutants into T cells lacking CD38 provided further evidence supporting the understanding that CD38 plays a crucial role in producing the immunosuppressive metabolite adenosine and utilizing nicotinamide adenine dinucleotide (NAD) in human T cells. Taken together, these results highlight a role for CD38 as an immunometabolic checkpoint in T cells and lead us to propose CD38 deletion as an additional avenue for boosting CAR T cell function.
Topics & Concepts
Chimeric antigen receptorCD38CD19AntigenReceptorFunction (biology)ImmunologyBiologyT cellCell biologyGeneticsImmune systemStem cellCD34CAR-T cell therapy researchSilicon Carbide Semiconductor TechnologiesImmune Cell Function and Interaction