Transitional B cell cytokines predict renal allograft outcomes
Aravind Cherukuri, Alan D. Salama, Rajil Mehta, Kanishka Mohib, Leting Zheng, Ciara N. Magee, Mark Harber, Hans J. Stauss, Richard J. Baker, Amit D. Tevar, Douglas Landsittel, Fadi G. Lakkis, Sundaram Hariharan, David M. Rothstein
Abstract
= 95) and in key patient subgroups, confirming generalizability. Biomarker high-risk patients exhibited progressively worse renal function and decreased 5-year graft survival compared to low-risk patients. Treatment of B cells with anti-TNFα in vitro augmented the IL-10/TNFα ratio, restored regulatory activity, and inhibited plasmablast differentiation. To conclude, the T1B IL-10/TNFα ratio was validated as a strong predictive biomarker of renal allograft outcomes and provides a rationale for preemptive therapeutic intervention with TNF blockade.