Novel PROTACs for degradation of SHP2 protein
Mengzhu Zheng, Yang Liu, Canrong Wu, Kaiyin Yang, Qiqi Wang, Yirong Zhou, Lixia Chen, Hua Li
Topics & Concepts
ChemistryHeLaProtein tyrosine phosphataseCancer researchCancerAllosteric regulationPhosphataseCancer cellApoptosisCell biologyPhosphorylationCellBiochemistryEnzymeBiologyGeneticsProtein Tyrosine PhosphatasesPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways