Progress in the catalytic enantioselective construction of difluoroalkylated stereogenic centers
Li‐Juan Tang, Yongshun Wen, Hong-Xian Jin, Wenjun Luo, Lipeng Long, Jiayi Shen, Haiqing Luo, Daohong Yu
Abstract
This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
Topics & Concepts
StereocenterEnantioselective synthesisChemistryCatalysisCenter (category theory)Combinatorial chemistryStereochemistryOrganic chemistryCrystallographyFluorine in Organic Chemistry