<i>O</i> -GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis
Jinsu Park, Hee-Jin Ha, Eun Seon Chung, Seung Hyun Baek, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Ryoul Yang, Mikyoung Park, Sung Hyun Kim, Thiruma V. Arumugam, Hyemin Jang, Sang Won Seo, Pann‐Ghill Suh, Dong‐Gyu Jo
Abstract
Increased O -GlcNAcylation can confer neuroprotective effects against necroptosis in the context of Alzheimer’s disease.
Topics & Concepts
NecroptosisContext (archaeology)DiseaseNeuroprotectionPathologicalNeuroscienceAlzheimer's diseaseMedicineBiologyPathologyApoptosisProgrammed cell deathGeneticsPaleontologyGlycosylation and Glycoproteins ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms