Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
Rongxiang Chen, Shaohong Xu, Fumin Shen, Canran Xu, Kai‐Kai Wang, Zhan‐Yong Wang, Lantao Liu
Abstract
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.
Topics & Concepts
SulfonylChemistryHydrazideNucleophileOrganic chemistryCombinatorial chemistryCatalysisAlkylSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions