UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
Kejing Zhang, Wang Ailian, Keke Zhong, Shuyuan Qi, Wei Chen, Xiaoqiu Shu, Wen-Yo Tu, Wentao Xu, Congcong Xia, Yatao Xiao, Aizhong Chen, Lei Bai, Jianmin Zhang, Benyan Luo, Wenyuan Wang, Chengyong Shen
Topics & Concepts
C9orf72Frontotemporal dementiaAmyotrophic lateral sclerosisProtein aggregationNeurotoxicityHsp70Frontotemporal lobar degenerationNeuroscienceTrinucleotide repeat expansionCell biologyChemistryBiologyBiophysicsDementiaGeneMedicineHeat shock proteinBiochemistryToxicityPathologyAlleleDiseaseOrganic chemistryAmyotrophic Lateral Sclerosis Researchbiodegradable polymer synthesis and propertiesPrion Diseases and Protein Misfolding