BRAF/MEK inhibition in NSCLC: mechanisms of resistance and how to overcome it
Ioannis Tsamis, Georgia Gomatou, Stavroula Porfyria Chachali, Ioannis P. Trontzas, Vasileios Patriarcheas, Εmmanouil Panagiotou, Ηλίας Κοττέας
Topics & Concepts
MedicineEffectorMAPK/ERK pathwayPI3K/AKT/mTOR pathwayCancer researchLung cancerProtein kinase BCancerTargeted therapyMechanism (biology)BioinformaticsSignal transductionOncologyImmunologyInternal medicineBiologyGeneticsEpistemologyPhilosophyMelanoma and MAPK PathwaysCancer Mechanisms and TherapySynthesis and biological activity