Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration
Olena Synhaivska, Shayon Bhattacharya, Silvia Campioni, Damien Thompson, Peter Niraj Nirmalraj
Abstract
ions. Our findings emphasize the importance of targeting annular α-Syn protein oligomers for therapeutic intervention and their potential role as biomarkers for early detection and monitoring progression of neurodegeneration.
Topics & Concepts
NeurodegenerationChemistryBiophysicsMonomerRaman spectroscopyProtein aggregationFibrilAtomic force microscopyIonForce spectroscopyNanotechnologyBiochemistryMaterials scienceBiologyDiseaseMedicinePathologyPolymerPhysicsOpticsOrganic chemistryParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsElectrochemical Analysis and Applications