Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives
Yu. A. Gracheva, Ekaterina S. Shchegravina, Hans‐Günther Schmalz, I. P. Beletskaya, Alexey Yu. Fedorov
Abstract
, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.
Topics & Concepts
ColchicineChemistryAlkaloidProdrugStereochemistryComputational biologyCombinatorial chemistryBiochemistryBiologyGeneticsSynthesis and biological activitySynthesis and Reactivity of HeterocyclesSynthesis of heterocyclic compounds