Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of <i>Alstonia scholaris</i>
Bin‐Yuan Hu, Yun‐Li Zhao, Deng‐Sen Xiong, Yingjie He, Zhong-Shun Zhou, Peifen Zhu, Zhao‐Jie Wang, Yongliang Wang, Li‐Xing Zhao, Xiao‐Dong Luo
Abstract
Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris. Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo.
Topics & Concepts
ChemistryTriterpenoidStereochemistryCircular dichroismRing (chemistry)Organic chemistryNatural product bioactivities and synthesisAlkaloids: synthesis and pharmacologyTraditional and Medicinal Uses of Annonaceae