CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis
Baoxing Liu, Haibo Ma, Xingyu Liu, Wenqun Xing
Abstract
. Moreover, circSCN8A promoted cell ferroptosis in NSCLC. Mechanistically, circSCN8A acted as a competing endogenous RNA (ceRNA) by sponging miR-1290 to enhance the expression of long-chain acyl-CoA synthetase-4 (ACSL4). Furthermore, the knockdown of ACSL4 or overexpression of miR-1290 reversed the effect of circSCN8A on facilitating ferroptosis and inhibiting cell proliferation and metastasis. In summary, circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. Thus, circSCN8A may represent a promising therapeutic target against NSCLC.
Topics & Concepts
Competing endogenous RNAGene knockdownCancer researchCell growthLung cancerMetastasisEpithelial–mesenchymal transitionCellBiologyCell migrationCancerDownregulation and upregulationCell cultureMedicineLong non-coding RNAInternal medicineGeneGeneticsCircular RNAs in diseasesFerroptosis and cancer prognosisCancer-related molecular mechanisms research