In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis

Michael A. Gerber, Sanjay Goel, Radhashree Maitra

2021Computers in Biology and Medicine11 citationsDOI Open Access PDF

Topics & Concepts

KRASGTP'MutantIn silicoGuanosineGuanosine triphosphateGTPaseChemistrySmall moleculeWild typeBiochemistryBinding siteBiologyMutationComputational biologyEnzymeGeneProtein Kinase Regulation and GTPase SignalingEnzyme Structure and FunctionBiochemical and Molecular Research

In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&amp;II regions preventing GTP hydrolysis

Topics & Concepts

In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis