Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics
Charlotte M. J. Wesseling, Nathaniel I. Martin
Abstract
. In cases where the FICI values were not directly reported in the primary literature but could be calculated from the published data, we have done so, allowing for more direct comparison of potency with other synergists. We also address the hemolytic activity of the various OM-disrupting synergists reported in the literature, an effect that is often downplayed but is of key importance in assessing the selectivity of such compounds for Gram-negative bacteria.
Topics & Concepts
Acinetobacter baumanniiAntibioticsMicrobiologyGram-negative bacteriaBacteriaPseudomonas aeruginosaBacterial outer membraneNovobiocinPolymyxinGram-positive bacteriaBiologyGramMinimum inhibitory concentrationVancomycinChemistryEscherichia coliBiochemistryStaphylococcus aureusGeneticsGeneAntibiotic Resistance in BacteriaAntimicrobial Peptides and ActivitiesBacterial biofilms and quorum sensing