Visible-light induced copper(<scp>i</scp>)-catalyzed oxidative cyclization of <i>o</i>-aminobenzamides with methanol and ethanol <i>via</i> HAT
Mandapati Bhargava Reddy, Kesavan Prasanth, Ramasamy Anandhan
Abstract
)-H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.
Topics & Concepts
CopperMethanolEthanolCatalysisVisible spectrumChemistryLigand (biochemistry)Oxidative phosphorylationPhotochemistryMedicinal chemistryStereochemistryOrganic chemistryPhysicsReceptorBiochemistryOpticsQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsPhenothiazines and Benzothiazines Synthesis and Activities