Chelating Group Enabled Palladium‐Catalyzed Regiodivergent Carbonylative Synthesis of 2,3‐Dihydroquinolin‐4(1<i>H</i>)‐ones
Jun Ying, Jian‐Shu Wang, Lingyun Yao, Wangyang Lü, Xiao‐Feng Wu
Abstract
Py)-2-iodoanilines with terminal alkenes has been developed for the rapid construction of dihydroquinolin-4(1H)-one scaffolds. Enabled by the chelating group and using benzene-1,3,5-triyl triformate (TFBen) as the CO source, both aromatic and aliphatic alkenes were smoothly transformed into the corresponding 2,3-dihydroquinolin-4(1H)-ones in good yields with excellent regioselectivities. Notably, the reaction of aromatic alkenes produces 2-aryl-2,3-dihydroquinolin-4(1H)-ones, while 3-alkyl-2,3-dihydroquinolin-4(1H)-ones were obtained when aliphatic alkenes were used. This protocol has been applied in the synthesis of antitumor agent A as well.
Topics & Concepts
PalladiumChelationArylBenzeneCatalysisChemistryAlkylSulfonylMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions