Multi-site implementation of whole genome sequencing for hospital infection control: A prospective genomic epidemiological analysis
Norelle L. Sherry, Claire L. Gorrie, Jason C. Kwong, Charlie Higgs, Rhonda L. Stuart, Caroline Marshall, Susan A. Ballard, Michelle Sait, Tony M. Korman, Monica A. Slavin, Robyn S. Lee, Maryza Graham, Marcel Leroi, Leon J. Worth, Hiu Tat Chan, Torsten Seemann, M. Lindsay Grayson, Benjamin P. Howden
Abstract
Background: Current microbiological methods lack the resolution to accurately identify multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing can identify highly-related patient isolates providing opportunities for precision infection control interventions. We investigated the feasibility and potential impact of a prospective multi-centre genomics workflow for hospital infection control. Methods: (ESBL-Kp). Genomic and epidemiologic data were integrated to assess MDRO transmission. Findings: VRE becoming a notifiable condition. We identified barriers to implementation and recommend strategies for mitigation. Interpretation: Implementation of a multi-centre genomics-informed infection control workflow is feasible and identifies many unrecognised MDRO transmissions. This provides critical opportunities for interventions to improve patient safety in hospitals. Funding: Melbourne Genomics Health Alliance (supported by State Government of Victoria, Australia), and National Health and Medical Research Council (Australia).