Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin
Hayato Takahashi, Hiroyuki Nomura, Hisato Iriki, Akiko Kubo, Koichi Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yutaka Kurebayashi, Hiroki Yoshida, Akihiko Yoshimura, Hong‐Wei Sun, Makoto Suematsu, John J. O’Shea, Yuka Kanno, Masayuki Amagai
Abstract
led to worse outcomes. Thus, Ch25h is an immunoregulatory metabolic switch induced by IL-27 and dampens excess bystander T effector expansion in tissues through its metabolite derivative, 25OHC. This study reveals regulation of cholesterol metabolism as a modality for controlling tissue inflammation and thus represents a mechanism underlying T cell immunoregulatory functions.
Topics & Concepts
Bystander effectInflammationCholesterolBiosynthesisCellCell biologyBiologyChemistryEnzymeImmunologyBiochemistryCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesT-cell and B-cell Immunology