Green Method for the Synthetic Ugi Reaction by Twin Screw Extrusion without a Solvent and Catalyst
Mahmoud Abd El Aleem Ali Ali El‐Remaily, Ahmed M. Soliman, Omar M. Elhady
Abstract
This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solvent-free conditions, which lead to a more environmentally friendly process.
Topics & Concepts
ExtrusionCatalysisSolventEnvironmentally friendlyProcess (computing)Reaction conditionsReactive extrusionMaterials scienceChemical engineeringChemistryOrganic chemistryProcess engineeringComputer scienceMetallurgyEngineeringBiologyOperating systemEcologyMulticomponent Synthesis of HeterocyclesChemical Synthesis and AnalysisSynthesis and biological activity