<i>Toxoplasma</i> TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite
Linyan Cheng, Yuan Tian, Yan Wang, Tingting Wang, Yinning Yao, Helin Yu, Xiaozi Zheng, Mimi Wu, Wei Zhao, Qianqian Hua, Xin Hu, Feng Tan
Abstract
has adapted a conserved Atg8-Atg3 interaction, required for canonical autophagy in other eukaryotes, to function specifically in apicoplast inheritance. Our finding not only highlights the importance of TgAtg8-TgAtg3 interaction in tachyzoite growth but also suggests that this interaction is a promising drug target for the therapy of toxoplasmosis.
Topics & Concepts
ApicoplastBiologyATG8Cell biologyPlastidToxoplasma gondiiApicomplexaAutophagyGeneticsMutantOrganelleGenePlasmodium falciparumChloroplastImmunologyApoptosisMalariaAntibodyToxoplasma gondii Research StudiesParasitic Infections and DiagnosticsAutophagy in Disease and Therapy