Enzyme-responsive nanoparticles: enhancing the ability of endolysins to eradicate <i>Staphylococcus aureus</i> biofilm
Mariana Blanco Massani, Dennis To, Susanne Meile, Mathias Schmelcher, David Gintsburg, Débora C. Coraça‐Huber, Anna Seybold, Martin J. Loessner, Andreas Bernkop‐Schnürch
Abstract
The efficacy of peptidoglycan hydrolases (PGHs) to target staphylococcal biofilm is dramatically improved by forming enzyme-responsive polyphosphate nanoparticles (PGH–PP NPs).
Topics & Concepts
BiofilmPeptidoglycanLysinStaphylococcus aureusPolyphosphateMicrobiologyEnzymeChemistryBacteriaBiochemistryBiologyEscherichia coliBacteriophagePhosphateGeneGeneticsAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactionsOral microbiology and periodontitis research