Litcius/Paper detail

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Anna S. Nam, Neville Dusaj, Franco Izzo, Rekha Murali, Robert M. Myers, Tarek H. Mouhieddine, Jesús Alfonso López Sotélo, Salima Benbarche, Michael R. Waarts, Federico Gaiti, Sabrin Tahri, Ross L. Levine, Omar Abdel‐Wahab, Lucy A. Godley, Ronan Chaligné, Irene M. Ghobrial, Dan A. Landau

2022Nature Genetics132 citationsDOIOpen Access PDF

Topics & Concepts

BiologyDNA methylationTranscriptomeGeneticsMyeloidSomatic cellHaematopoiesisEpigeneticsPhenotypeProgenitor cellStem cellComputational biologyGeneCancer researchGene expressionAcute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomicsCancer Genomics and Diagnostics