Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
Anna S. Nam, Neville Dusaj, Franco Izzo, Rekha Murali, Robert M. Myers, Tarek H. Mouhieddine, Jesús Alfonso López Sotélo, Salima Benbarche, Michael R. Waarts, Federico Gaiti, Sabrin Tahri, Ross L. Levine, Omar Abdel‐Wahab, Lucy A. Godley, Ronan Chaligné, Irene M. Ghobrial, Dan A. Landau
Topics & Concepts
BiologyDNA methylationTranscriptomeGeneticsMyeloidSomatic cellHaematopoiesisEpigeneticsPhenotypeProgenitor cellStem cellComputational biologyGeneCancer researchGene expressionAcute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomicsCancer Genomics and Diagnostics