Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy
Changsheng Zhong, Yilin Xie, Huifang Wang, Wenxian Chen, Zhenbo Yang, Lei Zhang, Qin Deng, Ting Cheng, Mengyang Li, Jin Ju, Yanyan Liu, Haihai Liang
Topics & Concepts
PyroptosisInflammasomeBerberinePI3K/AKT/mTOR pathwayDiabetic cardiomyopathyPharmacologyChemistryMitochondrial ROSProtein kinase BInflammationCell biologyReactive oxygen speciesApoptosisInternal medicineMedicineBiologyCardiomyopathyBiochemistryHeart failureInflammasome and immune disordersBerberine and alkaloids researchAutophagy in Disease and Therapy