Pharmacological inhibition of cGAS ameliorates postoperative cognitive dysfunction by suppressing caspase-3/GSDME-dependent pyroptosis
Xueshan Bu, Ping Gong, Lei Zhang, Wenqin Song, Jiabao Hou, Qingwen Li, Wei Wang, Zhongyuan Xia
Topics & Concepts
PyroptosisMorris water navigation taskNeuroinflammationTUNEL assayPharmacologyProinflammatory cytokineHippocampusTerminal deoxynucleotidyl transferaseChemistryMedicineApoptosisImmunologyInflammasomeInflammationEndocrinologyBiochemistryInflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation