Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
Ao Wang, Yawan Wang, Xin Meng, Yushe Yang
Topics & Concepts
ChemistryAndrogen receptorProstate cancerProstateBiological activityCancerChemical synthesisAndrogenAntiandrogenReceptorPharmacologyIn vitroBiochemistryInternal medicineHormoneMedicineProstate Cancer Treatment and ResearchEstrogen and related hormone effectsCancer, Lipids, and Metabolism