WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA
Jiayi Wang, Jiehan Zhang, Yan Ma, Yuxiao Zeng, Cheng Lü, Fenghua Yang, Nianxin Jiang, Xuan Zhang, Yuhua Wang, Yinghui Xu, Hanjing Hou, Shengyang Jiang, Shaowei Zhuang
Abstract
A modification of ATF4 mRNA. These findings highlight the importance of WTAP in I/R injury and provide new insights into therapeutic strategies for MI.
Topics & Concepts
Endoplasmic reticulumReperfusion injuryMessenger RNAATF4Myocardial ischemiaIschemiaCell biologyUnfolded protein responseInternal medicineMedicineChemistryBiologyGeneBiochemistryRNA modifications and cancerCardiac Structural Anomalies and RepairPeptidase Inhibition and Analysis