NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer
Elaine Leung, Darren Ennis, Philippa R Kennedy, Christopher A.H. Hansell, Suzanne Dowson, Malcolm Farquharson, Pavlina Spiliopoulou, Jaya Nautiyal, Sophie McNamara, Leo M. Carlin, Kerry Fisher, Daniel M. Davis, Gerard J. Graham, Iain A. McNeish
Abstract
922-947 and enadenotucirev do not infect NK cells, but induce contact-dependent activation and anti-cancer cytotoxicity against adenovirus-infected ovarian cancer cells. Moreover, manipulation of NK receptors DNAM-1 (DNAX accessory molecule-1) and TIGIT (T cell immunoreceptor with Ig and ITIM domains) significantly influences NK cytotoxicity against adenovirus-infected cells. Together, these results indicate that NK cells act to increase the activity of oncolytic adenovirus in ovarian cancer and suggest that strategies to augment NK activity further via the blockade of inhibitory NK receptor TIGIT could enhance therapeutic potential of OVs.